【摘要】 目的 评价牙周炎患者局部应用米诺四环素对其龈沟液中胶原酶活性的影响及其临床疗效。方法 采用单盲随机对照法,选择31例慢性牙周炎患者，分为用药组和对照组，每组各60个探诊深度＞5 mm且探诊后出血的牙位点。在基线前须完成全口龈上洁治及口腔卫生宣教。检查:基线时试验牙取龈沟液样本（测定胶原酶）,记录菌斑指数、探诊深度、附着丧失和探诊出血，然后行龈下刮治术,用药侧每周放1次药，共4次，对照侧不放药。第4、7、11周的检查同上。结果 用药组龈沟液中胶原酶水平与其基线、对照组相比明显下降（P＜0.01），其他各项临床指标的改善也更为明显。结论 应用米诺四环素软膏作为牙周炎基础治疗的辅助疗法，能有效降低龈沟液中胶原酶活性水平，从而有效地阻止牙周组织的破坏。
The effect of non-surgical periodontal and adjunctive minocycline-HCL treatments on collagenase activity
GENG Sufang, CAO Caifang, CHEN Zhibin, et al.
(Department of Periodontology, School of Stomatology, Beijing Medical University, Beijing 100081，China)
【Abstract】 Objective To evaluate the effect of scaling and root planing combined with local application of 2% minocycline hydrochoride ointment（Periocline） on the level of collagenase activity releasing from PMNs in GCF. Methods This was a randomized, single-blinded, split mouth design study. The target sites of 31 patients with moderate to severe periodontitis (PD＞5 mm) was randomized by left-side and right-side into one of the two groups (the test group and the control group). Subsequently each patient was scheduled for two appointments for the full-month supra-gingival scaling and oral hygiene instruction. At baseline all patients received subgingival scaling and root planing and were followed by 4-time applications of Periocline with one-week interval for totally four weeks in the test group. All patients were taken GCF for measuring collagenase by
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