摘　要：目的　本研究对40例口腔扁平苔藓(OLP)患者及40名对照组患者分别用干湿全自动生化分析仪、酶链免疫吸附试验(ELZSA)及多聚酶链反应(PCR)检测外周血ALT、抗-HCV和HCV-RNA、以探讨HCV感染与OLP之间的关系。结果　40名OLP患者中，10例(25.0％)有ALT异常，8例(20.0％)抗-HCV阳性，7例(17.5％)HCV-RNA阳性，经统计学处理有显著性差异(P＜0.05、P＜0.01、P＜0.01)，同时对两例血清HCV-RNA阳性的OLP患者用PCR法进一步检测其口腔病损组织中的HCV-RNA均为阴性。结果提示：OLP患者中HCV的高感染率，以及部分OLP患者体内有HCV-RNA存在与复制,说明部分OLP的发病可能与HCV感染有一定的关系。

　　分类号：R781.59　Q939.47　文献标识码：A

　　文章编号

Oral Lichen Planus And Hepatitis C virus lnfection Assessing The Association Between Them

Wu Guoyin

　　(Stomatological college,Nanjing Medical University,Nanjing 210029)

　　Abstract：To assess the association between oral lichen planus (OLP) and hepatitis C virus (HCV) infection.We selected 40 patients with OLP and 40 control patients to analysed the presence of HCV in peripheral blood by dry-wet automatic biochemical analysis,antibodies to HCV by enzyme-immunossay and HCV-RAN by polymerase chain reaction (PCR).We found that: in these 40 patients with OLP 10(25%) had abnormal ALT,8 Patients(20.0%) had antibodies to HCV positive,and in 7(17.5%)patients HCV-RAN was detected.Also,they had significant difference(P＜0.05，P＜0.01，P＜0.01)by statistial analysis.Further more,we detected the HCV-RNA in oral erosive tissure by polym,erase chain reaction(PCR) in two patients with positive serum HCV-RNA,both were negtive.The result indicats:The high prevemlence of HCV in patients w

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