提　要　为了探索口腔扁平苔藓（OLP）与系统疾病的关系，本研究以系统因素中的消化系统为背景，应用PCR技术对90例OLP患者进行了幽门螺旋杆菌（HP）检测。结果显示：在90例OLP患者中，其中60例表现为口腔粘膜损害区HP阳性，与正常组相比具有高度显著性差异（P＜0．01）；对其中45例OLP患者作胃镜检查并进行病变区胃粘膜的HP检测，发现45例OLP患者均患有不同程度与类型的慢性胃炎，且HP检出率与正常对照组相比亦具有高度显著性差异（P＜0.01）。说明OLP与慢性胃炎可能具有相似的发病机制,同时，HP很可能是OLP的直接致病菌。

The effect of helicobacter pylori in the pathogenic process of oral lichen planus.

Zhang Shuilong, et al.

Department of Oral Medicine, Ninth Peoples Hospital, Shanghai Second Medical Univeristy, Shanghai 200011.

　　Abstract　In order to quest the relationship between oral lichen planus (OLP) and systematic diseases, this study was based on the background of digestive diseases in systemic factors, and PCR was applied to detect helicobacter pylori(HP) in the lesions of 90 OLP cases. The results showed:(1) 60 of 90 OLP cases had positiveness of HP, and there was significant difference comparing with control group（P＜0.01）; endoscope was adopted to examine HP in stomach mucosal lesions in 45 of 90 OLP patients. There was also significant difference between 45 OLP cases and contral group（P＜0.01）,and they suffered from different types of chronic gastritis(CG). It is illustrated that OLP and CG may have resemble mechanism, in the meantime, HP may be the direct pathogenic factor of OLP.

　　Key words　Oral Lichen Planus　　PCR　　Helicobacter Pylori

　　实验证明各型慢性胃炎的致病菌是幽门螺旋杆菌（Helicobacter Pylori,简称HP）［1］，提示HP与OLP具有某种

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