[Abstract] Bone marrow transplantation is one of therapeutic choices for many leukemias , lymphomas , bone marrow failure syndromes and immunodeficiency disorders, and is the primary and salvage therapy for many solid malignancies. But, graft-versus-host disease remains a major complication of allergeneic bone marrow transplantation. The skin, mucosa, gastrointestinal tract and liver are target
organs. Oral finding including ulceration, mucositis, leukoplakia, erythema, xerostomia, progressive salivary gland atrophy and so on are seen in graft-versus-host disease. It causes significant morbidity and mortality after bone marrow transplantation. More and more scholars and clinical doctors have noticed it and do many study to try to prevent and treat graft- versus-host disease. But the pathogenesis of graft-versus-host disease is still uncertain. This article gives graft-versus-host disease a brief review in causing, clinlic finding, laboratory examination, treatment and focus on oral manifestation of graft-versus-host disease.
[Key words] bone marrow transplantation, graft-versus-host disease, oral manifestation
[摘要] 骨髓移植（BMT）是许多白血病，淋巴瘤，骨髓功能低下综合症和免疫缺陷紊乱症的一种有效治疗手段，也是许多实性恶性肿瘤的首选治疗手段之一。但是，移植物抗宿主病（GVHD）仍然是骨髓移植的主要并发症。皮肤，粘膜，胃肠道与肝脏均可成为攻击的靶器官。口腔表现诸如粘膜炎，溃疡，白斑，红斑，口干症，进行性唾液腺萎缩等等，在移植物抗宿主病中均可见。其发生率与死亡率之高成为骨髓移植的最大障碍。越来越多的临床医师和学者已经注意到这点并进行了许多方面的研究试图预防与治疗移植物抗宿主病，但是该病的具体发病机制尚有待讨论。本文就移植物抗宿主病的发生，在口腔的临床
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