口腔粘膜癌前病变脱落细胞微核计数的研究
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摘要 目的：探讨在口腔粘膜癌前病变中，用无创的脱落细胞涂片检查进行微核计数的临床意义。方法：对75例口腔癌前病变或口腔癌患者和90例对照者进行了口腔粘膜脱落细胞微核计数的分析。结果：白斑和鳞癌患者病损处细胞微核数高于扁平苔藓患者及正常人。（P<0.001）结论：白斑较扁平苔藓更易产生染色体损伤，形成微核，进而具有更大的恶变潜能。微核的出现预示着癌前病变发生的早期。关键词：微核 脱落细胞 癌前病变
Studies of micronuclei in oral exfoliative cells of precancerous lesion. ZHOU Xuan, LIU Hongwei, GAO Yan. School of Stomatology, Beijing University, Beijing. 100081
[ABSTRACT] O
bjective: To evaluate the diagnostic significance of micronucleus assay by using exfoliative cytological examination. Methods: 75 patients were selected, including 39 patients with leukoplakia (Lk), 15 patients with lichen planus (LP) and 21 patients with oral squamous cell carcinoma (SCC). Cells were scrapped from the lesions. The frequency of micronucleated(MN) cells was calculated. Results: The mean percentage of MN cells in the lesions of Lk or SCC is significantly higher than both in normal individuals and in patients with LP(P<0.001). Conclusion: Lk is more likely to have chromosome breakage and malignant transformation than LP. The micronucleus test is applicable to observe the early change of pre-malignant lesion. Key Words: micronuclei exfoliative cell precancerous lesion
白斑和红斑是世界公认的癌前病变。扁平苔藓被称为癌前状态。对这些病变患者的普查是很重要的防癌步骤。癌前病变的诊断依赖于组织活检，但并非每个患者都能接受手术介入的方法。因此，无创的检查方法，如脱落细胞微核计数等，其临床意义值得研究。微核是染色体损伤的标志。口腔粘膜脱落细胞微核计数反映了口腔上皮暴露于致癌物或诱变剂后的染色体损伤，在肿瘤监控中有一定作用。现今，微核计数在国外已被广泛用于临床和基础研究。在口腔研究中，多用于癌症的高危人群，如吸烟者、白斑患
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