〔摘要〕 目的：了解OLP患者HCV感染情况，探讨HCV感染与OLP之间的关系。方法：用全自动生化检测仪，酶联免疫测定及PCR法分别测定41名OLP患者和38名对照者外周血SGPT、SGOT、抗-HCV和HCV-RNA。结果：41名OLP患者中，15人(36.6%)有肝酶异常升高、12人(29.3%)抗-HCV阳性，10人(24.4%)HCV-RNA阳性；而38名对照组中，6人(15.8%)有肝酶异常升高，3人(7.9%)抗-HCV阳性，3人(7.9%)HCV-RNA阳性，OLP组的上述三项指标均较对照组为高(P＜0.05、P＜0.01、P＜0.05)，两组存在明显的差异。结论：国人OLP患者存在较高的HCV感染率，表明有相当部份的OLP患者体内有HCV存在与复制，OLP的发病可能与此有一定的关系。
A preliminary study of hepatitis
C virus
infection in the patients with oral lichen planus.
Huang Huafeng.
Department of Stomatology,Jinling Hospital,Nanjing 21002
〔Abstract〕 Objective:To investigate the infectious condition of hepatitis C virus (HCV) in the patients with oral lichen planus (OLP) and to study the relationship between OLP and HCV infection.Methods:The SGPT,SGOT,anti HCV antibodies and HCV-RNA in the serum samples of the 41 OLP patients and 38 controls were examined respectively by the auto-biochemical assay,enzyme-immunoassay (EIA) and polymerase chain reaction(PCR).Results:In the 41 OLP patients and 38 controls,15(36.6%) patients and 6(15.8%) controls had abnormal liver transaminase level (P＜0.05);12(29.3%) and 3 (7.9%) positve anti-HCV antibodies (P＜0.01);10(24.4%)and 3(7.9%)positive HCV-RNA(P＜0.05);Conclusion:OLP patients have a high HCV infection rate.OLP might be related to the existence and reproduction of HCV to a certain extent.
Key words Lichen planus;Hepatitis C virus;Viral RNA;Po
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